Compendium of Medicating Ingredient Brochures (CMIB)

8^th Edition

April 2008

• CMIB Table of Contents

Please note the following major changes that will be included in the consolidated version of the CMIB at the next printing:

1. MIB # 10.7 - Penicillin from Procaine Penicillin
   • Changed the brand name from APA PEN-P 110 to PEN-P 110.
   • Changed the brand name from APA PEN-P 100 to PEN-P 1000.
   • Vétoquinol N.-A. Inc., is the new sponsor for PEN-P 110 and PEN-P 1000.
   • Deleted one brand called VETO-PEN (Vétoquinol N.-A. Inc.)
2. MIB # 10.14 - Zinc Bacitracin and Procaine Penicillin (deleted)
   • Deleted one brand called BACIFERM-PB-50 (Cynamid Canada Inc.).
   • Deleted MIB #10.14 Zinc bacitracin and Procaine Penicillin.
3. MIB # 21 - 3-Nitro-4-Hydroxyphenylarsonic acid
   • Deleted one brand called 3-NITRO-4-HYDROXYPHENYLARSONIC ACID 20% (Davis & Lawrence).
4. MIB # 34 - Chlortetracycline Hydrochloride
   • Added one new claim (claim #42): As an aid in the prevention of porcine proliferative enteropathy (ileitis) caused by Lawsonia intracellularis sensitive to chlortetracycline HCI.
5. MIB # 43 - Tylosin Phosphate
   • Added 2 new claims (added claims 5 and 6).
   • Claim 5: As an aid in the treatment of porcine proliferative enteropathy (ileitis), associated with Lawsonia intracellularis when used following treatment with Elanco Tylan Soluble.
   • Claim 6: As an aid in the treatment of necrotic enteritis caused by Clostridium perfringens in broiler chickens.
6. MIB # 46 - Melengestrol Acetate
   • Changed withdrawal time (from 48 hours to 24 hours) for feeds containing MGA 100 PREMIX.
7. MIB # 57 - Monensin Sodium
   • Deleted the statement: NOTE: MONENSIN PREMIX is approved only for claims 1, 2, 3, 4 & 5
   • Added 3 new claims for COBAN PREMIX: (added claims 6, 7, and 8).
   • Under Claim #2; removed Caution statement #4 for Coban and Rumensin Premixes.
   • Under Claim #2; modified Directions for Use for Coban and Rumensin Premixes only.
   • Under Claim #1; deleted Caution statement #2.
   • Modified directions for use under Claims 3, 4, 6, 7, and 8 (ie deleted the statement; " This calculation has been made for a wide range of body weights, using six different dry matter intake levels and is presented in "Daily Intake of Monensin Activity" tables found in the Rumensin Technical Reference Guide Addendum, or is available from the manufacturer in the case of Monensin Premix".
8. MIB # 66 - Lasalocid Sodium
   • Added the following minerals to the list of approved medicated minerals under claim #4:
     • Peace Country Pasture Cattle Mineral 200, Grande Prairie Feed Service (1971) Ltd.
     • Lifeline Pasture Cattle Mineral Bovatec, Landmark Feeds Inc.
     • Bovatec FC Pasture Cattle Mineral 200, V-S Feed and Agri Supplies Ltd.
     • Co-op Bovatec Pasture Cattle Mineral, Federated Co-operatives Limited.
   • Lasalocid sodium at the 105 mg/kg drug level is compatible with 55 mg/kg zinc bacitracin (MIB# 37A, Claim 2) for use in feeds for broiler chickens.
9. MIB # 67 - Tylosin phosphate and sulfamethazine
   • Under Claim 1, revised the bacterial name from Corynebacterium pyogenes to Actinomyces pyogenes to Arcanobacterium pyogenes.
10. MIB # 68 - Lincomycin
    • Changed withdrawal time from 2 days to 1-day for feeds containing LINCOMYCIN 44 PREMIX; LINCOMYCIN 110 PREMIX, LINCOMYCIN 44 G PREMIX; and LINCOMYCIN 110 G PREMIX at drug level of 220 mg/kg of complete feed.
    • New zero withdrawal time for feeds containing LNCOMYCIN 44 PREMIX; LINCOMYCIN 110 PREMIX, LINCOMYCIN 44 G PREMIX; and LINCOMYCIN 110 G PREMIX at drug level of 110 mg/kg of complete feed.
11. MIB #69 - Salinomycin Sodium
    • Added one new brand called BIO-COX 120 G PLUS PREMIX (Alpharma Canada Corporation).
    • Huvepharma is the new sponsor for SACOX 120 MEDICATED PREMIX.
12. MIB # 78 - Ivermectin
    • Changed withdrawal time from 5 days to 14 days for feeds containing Ivermectin when fed to breeding sows.
    • Added one new brand called NOROMECTIN PREMIX FOR SWINE (Norbrook Laboratories Limited).
13. MIB # 80 - Tilmicosin
    • Added one new claim (Claim #2): As an aid in reducing the severity of porcine polyserositis and arthritis associated with Haemophilus parasuis (Glasser's Disease) when fed to pigs approximately 7 days prior to anticipated disease outbreak.
14. MIB # 82 - Ractopamine hydrochloride
    • Added one new brand called OPTAFLEXX 100 Premix (Elanco, Division Eli Lilly Canada Inc.)
    • Added 2 new claims for OPTAFLEXX: (added claims 3 and 4).
    • Deleted one brand called PAYLEAN 100 PREMIX (Elanco, Division Eli Lilly Canada Inc.)
    • Revised Claim #3 and Claim #4 to include a restriction to the use of this product to confined cattle greater than 400 kg body weight.

In addition, please note the following minor changes that will be included in the consolidated version of the CMIB at next printing:

1. MIB #4 - Arsanilic Acid
   • Vétoquinol N.-A. Inc., is the new sponsor for Pro-Gen 20% and Pro-Gen 100%.
2. MIB #7 - Zoalene
   • Huvepharma is the new sponsor for ZOAMIX MEDICATED PREMIX.
3. MIB #10.12 - Bambermycins
   • Huvepharma is the new sponsor for FLAVOMYCIN 4 ANTIBIOTIC PREMIX.
4. MIB #19 - Piperazine
   • Vétoquinol N.-A. Inc., is the new sponsor for PIPERAZINE 52.
5. MIB #34 - Chlortetracycline Hydrochloride
   • Vétoquinol N.-A. Inc., is the new sponsor for CHLOROSOL 50 PREMIX.
6. MIB #35 - Oxytetracycline Hydrochloride
   • Vétoquinol N.-A. Inc., is the new sponsor for OXYSOL 110, OXYSOL 220 and OXYSOL 440.
7. MIB #38 - Chlortetracycline Hydrochloride, Sulfamethazine and Procaine Penicillin
   • Vétoquinol N.-A. Inc., is the new sponsor for CHLOROSOL-250 PREMIX and SUPER CHLOROSOL-250 PREMIX.
8. MIB #45 - Clopidol
   • Huvepharma is the new sponsor for COYDEN 25 ANTICOCCIDIAL PREMIX.
9. MIB #56 - Poloxalene
   • Phibro Animal Health Limited is the new sponsor for BLOAT-GUARD.
10. MIB #62 - Lincomycin and Spectinomycin
    • Pfizer Canada Inc., is the new sponsor for L-S 20 PREMIX
11. MIB #74 - Tiamulin
    • Novartis Animal Health Canada Inc., is the new sponsor for DENAGARD MEDICATED PREMIX.
12. MIB #76 - Halofuginone Hydrobromide
    • Huvepharma is the new sponsor for STENOROL PREMIX.
    • Under Claim #1, replaced E. mitis with E. mivati.

For additional information please contact:

Animal Feed Division
59 Camelot Drive
Ottawa, Ontario
K1A 0Y9

Telephone: 613-225-2342
Facsimile: 613-228-6614