Tylosin Phosphate - MIB #43

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Revised July 2017

Approved Brands

  1. Tylan 10 Premix contains tylosin (as tylosin phosphate) at 22 g/kg (Elanco)
  2. Tylan 40 Premix contains tylosin (as tylosin phosphate) at 88 g/kg (Elanco)
  3. Tylan 100 Premix contains tylosin (as tylosin phosphate) at 220 g/kg (Elanco)
  4. Tylosin 10 Premix contains tylosin (as tylosin phosphate) at 22 g/kg (Bio Agri Mix LP)
  5. Tylosin 40 Premix contains tylosin (as tylosin phosphate) at 88 g/kg (Bio Agri Mix LP)
  6. Pharmasin 100 Premix contains tylosin (as tylosin phosphate) at 220 g/kg (Huvepharma AD)

Approved for use

In meal or pellet feed for swine, broiler chickens and beef cattle.

Approved claims

For swine - Claims 1, 2, 3, 5, 7, 8
For beef cattle - Claim 4
For broiler chickens - Claim 6

Claim 1, 2, 3 and 4 – approved with the use of all premixes
Claim 5, 6, 7 and 8 – approved with the use of all Tylan premixes, Tylosin 40 and Pharmasin 100.

Note:

Positive diagnosis by a veterinarian is essential before using tylosin phosphate for the treatment and prevention of swine dysentery or porcine proliferative enteropathy, or for the treatment of necrotic enteritis in broiler chickens.

Claim 1: As an aid in treatment of Swine Dysentery (bloody scours, bloody diarrhea, black scours, hemorrhagic colitis, vibrio)

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for three weeks. Tylosin tartrate medicated drinking water should be provided concurrent with this medicated feed for the first three days of treatment or until symptoms disappear. Following this treatment, a prophylactic swine feed is to be fed.

Note:

Treatment following positive diagnosis involves placing the swine on medicated feed as well as water medication consisting of one gram of tylosin tartrate per 3.785 litres of drinking water. This should be given for three days or until symptoms disappear.

Warning:

  1. Swine treated concurrently with this drug in the complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.
  2. Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

  1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)
  2. Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)
  3. When treating swine dysentery, the diagnosis should be redetermined in cases of lack of response within 3 to 5 days of treatment commencement.

Claim 2: As an aid in prevention of cyclic recurrence following treatment of Swine Dysentery. (bloody scours, bloody diarrhea, black scours, hemorrhagic colitis, vibrio)

Level of Drug:

44 mg/kg (0.0044%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration until hogs reach market weight.

Note:

Swine Dysentery appears sporadically in swine herds in Canada.

Warning:

  1. Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

  1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)
  2. Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

Claim 3: As an aid in the prevention of Porcine Proliferative Enteropathy (PPE) or ileitis associated with Lawsonia intracellularis

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for 21 days, commencing prior to an anticipated outbreak of disease.

Warning:

  1. Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

  1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)
  2. Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

Claim 4: To reduce the incidence of liver abscesses caused by Arcanobacterium pyogenes (formerly Actinomyces pyogenes) and Fusobacterium necrophorum in beef cattle (steers and heifers) fed in confinement for slaughter

Level of Drug in Complete Diet:

11 mg/kg (0.0011%) tylosin in the complete diet including roughage (100% Dry Matter Basis)

Direction:

Feed continuously as the sole ration.

Note:

Tylan 10 Premix, Tylan 40 Premix and Pharmasin 100 Premix are approved to be used in the following thixotrope liquid supplements:

  1. HCS, Nutrena Feeds, Cargill Limited.
  2. Promolas Liquid Supplement Suspension, Westway Feed Products

Warning:

  1. Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

  1. Do not feed to replacement, breeding or lactating cattle.
  2. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)
  3. Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)
  4. Do not use thixotropic supplements after four weeks storage. (Required on Cargill thixotropic liquid supplement labels only.)
  5. Do not use thixotropic supplements after eight weeks storage. (Required on Promolas Liquid Supplement Suspension and Westway Feed Products thixotropic liquid supplement labels only.)

Claim 5: As an aid in the treatment of porcine proliferative enteropathy (PPE) or ileitis, associated with Lawsonia intracellularis when used following treatment with either Elanco Tylan Soluble, Tylosin Soluble Powder or Huvepharma Pharmasin Soluble

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for 7 days following treatment with Elanco Tylan Soluble or Tylosin Soluble Powder or Huvepharma Pharmasin Soluble.

Note:

Treatment following positive diagnosis involves placing the swine on water medication consisting of one gram of Elanco Tylan Soluble, Tylosin Soluble Powder or Huvepharma Pharmasin Soluble per 12 litres of drinking water (83 mg per litre) for 7 days followed by Elanco Tylan Premix, Bio Agri Tylosin 40 Premix or Huvepharma Pharmasin 100 Premix in feed at a rate of 110 mg/kg of complete feed for 7 days.

Warning:

  1. Swine treated concurrently with this drug in the complete feed with either Elanco Tylan Soluble or Tylosin Soluble Powder or Huvepharma Pharmasin Soluble in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.
  2. Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

  1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)
  2. Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)

Claim 6: As an aid in the treatment of necrotic enteritis caused by Clostridium perfringens in broiler chickens

Level of Drug:

200 mg/kg (0.020%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for 7 days.

Warning:

  1. Do not use in laying hens.
  2. Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

  1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)
  2. Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)
  3. When treating necrotic enteritis, the diagnosis should be redetermined in cases of lack of response within 3 to 5 days of treatment commencement.

Claim 7: For the treatment of porcine proliferative enteropathy (PPE) or ileitis, associated with Lawsonia intracellularis

Level of Drug:

110 mg/kg (0.011%) tylosin in the complete feed.

Direction:

Feed this medicated feed as the sole ration for three weeks.

Warning:

  1. Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

  1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)
  2. Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)
  3. When treating Porcine Proliferative Enteropathy the diagnosis should be confirmed by a veterinarian when results are not satisfactory.

Claim 8: For the treatment of porcine proliferative enteropathy (PPE) or ileitis, associated with Lawsonia intracellularis in the presence of persistent or recurring infection

Level of Drug:

  1. 110 mg/kg (0.011%) tylosin in the complete feed for 3 weeks.
  2. 44 mg/kg (0.0044%) tylosin in the complete feed for the following 3 weeks.

Direction:

  1. Feed 110 mg/kg (0.011%) medicated feed as the sole ration for 3 weeks This must be followed by 44 mg/kg medicated feed for the next 3 weeks.
  2. Feed 44 mg/kg (0.0044%) medicated feed as the sole ration for 3 weeks only after having fed 110 mg/kg medicated feed for 3 weeks.

Warning:

  1. Keep out of reach of children. (Required on premix and supplement labels only.)

Caution:

  1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Required on premix and supplement labels only.)
  2. Do not use in feeds containing bentonite. (Required on premix and supplement labels only.)
  3. When treating Porcine Proliferative Enteropathy the diagnosis should be confirmed by a veterinarian when results are not satisfactory.

Accepted Compatibilities

Tylosin phosphate is compatible in single combination with the following drugs. For details, refer to the MIB as indicated.
MIB # Medicated ingredients For use in feeds for
57 Monensin sodium (Claim 3 option 1a and option 2) feedlot beef cattle
Tylosin phosphate from Tylan and Tylosin premixes (Claim 4) is compatible with multiple drugs in the following combination. For details, refer to the MIB as indicated.
MIB #Medicated ingredients For use in feeds for

46

57

Melengestrol acetate AND

Monensin sodium (Claim 3 option 1b)

feedlot beef heifers
Date modified: