Chlortetracycline hydrochloride (CTC) – Medicating Ingredient Brochure

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Status: Veterinary prescription required for approved claims

Date of revision: April 2018

Table of approved species and claims
Approved livestock species Approved claim(s)
(abbreviated)Table note 1
Withdrawal time Name of approved brand(s)
Turkeys
  1. Aid in the prevention of Hexamitiasis
  2. Aid in treatment of Hexamitiasis
  3. Aid in the prevention of synovitis and infectious sinusitis
  4. Aid in the treatment of synovitis
7 days (meat)
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Swine
  1. Aid in prevention of bacterial enteritis
  2. Aid in the treatment of bacterial enteritis
7 days (meat)
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 50 Medicated Feed Premix
  3. Chlor 100 Granular Medicated Premix
  4. Deracin 22% Granular Premix
Swine
  1. Aid in the prevention of porcine proliferative enteropathy
7 days (meat)
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Beef and non-lactating dairy cattle
  1. Aid in the prevention of foot rot
5 days (meat)
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 50 Medicated Feed Premix
  3. Chlor 100 Granular Medicated Premix
  4. Deracin 22% Granular Premix
Calves (up to 136 kg)
  1. Aid in the prevention of bacterial diarrhoea.
5 days (meat)
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 50 Medicated Feed Premix
  3. Chlor 100 Granular Medicated Premix
  4. Deracin 22% Granular Premix
Calves (milk replacers)
  1. Aid in the prevention of bacterial diarrhoea.
5 days (meat)
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 50 Medicated Feed Premix
  3. Chlor 100 Granular Medicated Premix
  4. Deracin 22% Granular Premix
Lambs (feedlot)
  1. Aid in reduction of losses due to Enterotoxemia
4 days (meat)
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix

Turkeys

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claims 1, 2, 3, 4
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Chlortetracycline hydrochloride at 220 g/kg

Claim 1

As an aid in the prevention of Hexamitiasis. (This disease is not common in Canada. This product may be used on those farms having a history of this condition).

Level of medicating ingredient in a complete feed

55 mg/kg (0.0055%) of chlortetracycline hydrochloride in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration for as long as birds are expected to be exposed to infection.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 55 mg/kg (0.0055%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of finished (complete) feed:

  • 0.25 kg (250g) Aureomycin 220 G Granular Medicated Premix
  • 0.25 kg (250g) Chlor 100 Granular Medicated Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug when fed at the recommended level of 55 mg/kg (0.0055%) chlortetracycline hydrochloride in the complete feed.
  2. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Claim 2

As an aid in treatment of Hexamitiasis. (This disease is not common in Canada).

Level of medicating ingredient in a complete feed

110 mg/kg (0.011%) of chlortetracycline hydrochloride in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration for as long as birds are expected to be exposed to infection.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 110 mg/kg (0.011%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of finished (complete) feed:

  • 0.50 kg (500g) Aureomycin 220 G Granular Medicated Premix
  • 0.50 kg (500g) Chlor 100 Granular Medicated Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug when fed at the recommended level of 110 mg/kg (0.011%) chlortetracycline hydrochloride in the complete feed.
  2. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Claim 3

As an aid in the prevention of synovitis and infectious sinusitis.

Level of medicating ingredient in a complete feed

110 mg/kg (0.011%) of chlortetracycline hydrochloride in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration for as long as birds are expected to be exposed to the infection.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 110 mg/kg (0.011%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of finished (complete) feed:

  • 0.50 kg (500g) Aureomycin 220 G Granular Medicated Premix
  • 0.50 kg (500g) Chlor 100 Granular Medicated Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug when fed at the recommended level of 110 mg/kg (0.011%) chlortetracycline hydrochloride in the complete feed.
  2. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Claim 4

As an aid in the treatment of synovitis.

Level of medicating ingredient in a complete feed

220 mg/kg (0.022%) of chlortetracycline hydrochloride in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration when symptoms appear and continue for at least 2 weeks after symptoms disappear.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 220 mg/kg (0.022%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of finished (complete) feed:

  • 1.0 kg Aureomycin 220 G Granular Medicated Premix
  • 1.0 kg Chlor 100 Granular Medicated Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug when fed at the recommended level of 220 mg/kg (0.022%) chlortetracycline hydrochloride in the complete feed.
  2. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Accepted Compatibilities

Chlortetracycline hydrochloride is compatible with the following drug/drug combinations. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Chlortetracycline hydrochloride (turkeys)
Name of medicating ingredient MIB code Name of approved brand(s) Applicable claims
Amprolium AMP Amprol Feed Premix All claims
Zoalene ZOAF Zoamix Medicated Premix All claims

Swine

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claims 1, 2
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Chlortetracycline hydrochloride at 220 g/kg
Claims 1, 2
  1. Deracin 22% Granular Premix
Chlortetracycline calcium complex equivalent to chlortetracycline hydrochloride at 220 g/kg
Claims 1, 2
  1. Chlor 50 Medicated Feed Premix
Chlortetracycline (equivalent to chlortetracycline hydrochloride) at 110 g/kg
Claim 3
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Chlortetracycline hydrochloride at 220 g/kg

Claim 1

As an aid in prevention of bacterial enteritis (scours, bacterial diarrhea).

Level of medicating ingredient in a complete feed

55 mg/kg (0.0055%) of chlortetracycline hydrochloride in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration during the period of early growth up to 32 kg body weight.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 55 mg/kg (0.0055%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of finished (complete) feed:

  • 0.25 kg (250g) Aureomycin 220 G Granular Medicated Premix
  • 0.25 kg (250g) Chlor 100 Granular Medicated Premix
  • 0.25 kg (250g) Deracin 22% Granular Premix
  • 0.50 kg (500g) Chlor 50 Medicated Feed Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug when fed at the recommended level of 55 mg/kg (0.0055%) chlortetracycline hydrochloride in the complete feed.
  2. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)
Additional information to be added as notes to feed labels

Note

  1. Pre-starter and starter feeds to be fed up to and including 6 weeks of age should contain 220 mg/kg (0.022%) of chlortetracycline hydrochloride.

Claim 2

As an aid in the treatment of bacterial enteritis (scours, bacterial diarrhea).

Level of medicating ingredient in a complete feed

110 mg/kg (0.011%) of chlortetracycline hydrochloride in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed continuously as the sole ration following the appearance of symptoms and until 3 days after symptoms disappear.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 110 mg/kg (0.011%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of finished (complete) feed:

  • 0.50 kg (500g) Aureomycin 220 G Granular Medicated Premix
  • 0.50 kg (500g) Chlor 100 Granular Medicated Premix
  • 0.50 kg (500g) Deracin 22% Granular Premix
  • 1.0 kg Chlor 50 Medicated Feed Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug when fed at the recommended level of 110 mg/kg (0.011%) chlortetracycline hydrochloride in the complete feed.
  2. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)
Additional information to be added as notes to feed labels

Note

  1. Pre-starter and starter feeds to be fed up to and including 6 weeks of age should contain 220 mg/kg (0.022%) chlortetracycline hydrochloride.
  2. Pigs off feed should be given individual treatment.

Claim 3

As an aid in the prevention of porcine proliferative enteropathy (ileitis) caused by Lawsonia intracellularis sensitive to chlortetracycline hydrochloride.

Level of medicating ingredient in a complete feed

At a level in the complete feed such that each animal will receive 22 mg of chlortetracycline hydrochloride per kg of body weight per day.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed continuously as the sole ration for 14 days.

Additional information (not to appear on feed labels)

For feed manufacturers
Feed levels of this medication will vary according to feed intake and body weight. The appropriate feed level can be calculated as follows:

Feed level (mg/kg) = 22 mg/kg Body weight × Body weight (kg) ÷ Average Daily Feed Intake (kg)

The table below provides additional guidance.

Feed levels (mg chlortetracycline/kg of Complete Feed)
ADFITable note 2 (kg) Body Weight (kg)
kg 25 kg 50 kg 75 kg 100 kg 120 kg 250 kg
0.25 440 2,200
0.50 220 1,100 2,200 3,300
1.00 550 1,100 1,650 2,200 2,640
1.50 367 733 1,100 1,467 1,760
2.00 275 550 825 1,100 1,320
2.50 440 660 880 1,056
3.00 367 550 733 880 1,833
4.00 275 413 550 660 1,375

Warning

  1. Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug when fed at the recommended dose of 22 mg/kg body weight per day.
  2. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Accepted Compatibilities

Chlortetracycline hydrochloride is compatible with the following drug/drug combinations. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Chlortetracycline hydrochloride (swine)
Name of medicating ingredient MIB code Name of approved brand(s) Applicable claims
Tiamulin TIA
  1. Denagard Medicated Premix
  2. Tiamulin 1.78% Premix
Claims 1, 2
Tiamulin TIA
  1. Denagard 10% GF Premix
  2. Tiamulin HF 10% Premix
All claims

Beef and non-lactating dairy cattle

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1
  1. Chlor 50 Medicated Feed Premix
Chlortetracycline (equivalent to chlortetracycline hydrochloride) at 110 g/kg
Claim 1
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Chlortetracycline hydrochloride at 220 g/kg
Claim 1
  1. Deracin 22% Granular Premix
Chlortetracycline calcium complex equivalent to chlortetracycline hydrochloride at 220 g/kg

Claim 1

As an aid in the prevention of foot rot.

Level of medicating ingredient in a complete feed

At a level in the feed such that each animal will receive 0.22 mg of chlortetracycline hydrochloride per kg of body weight per day or 70 mg of chlortetracycline hydrochloride per head per day.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed continuously during the period animals are exposed to this disease.

Warning

  1. Treated animals must not be slaughtered for use in food for at least 5 days after the latest treatment with this drug when fed at the recommended rate of 70 mg of chlortetracycline hydrochloride per head per day.
  2. Do not administer to lactating dairy cattle.
  3. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  4. Keep out of reach of children. (Required on premix and supplement labels only)

Accepted Compatibilities

Nil

Calves (up to 136 kg)

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1
  1. Chlor 50 Medicated Feed Premix
Chlortetracycline (equivalent to chlortetracycline hydrochloride) at 110 g/kg
Claim 1
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Chlortetracycline hydrochloride at 220 g/kg
Claim 1
  1. Deracin 22% Granular Premix
Chlortetracycline calcium complex equivalent to chlortetracycline hydrochloride at 220 g/kg

Claim 1

As an aid in the prevention of bacterial diarrhea in calves.

Level of medicating ingredient in a complete feed

55 mg/kg (0.0055%) of chlortetracycline hydrochloride in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed continuously during periods of early growth.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 55 mg/kg (0.0055%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of finished (complete) feed:

  • 0.25 kg (250g) Aureomycin 220 G Granular Medicated Premix
  • 0.25 kg (250g) Chlor 100 Granular Medicated Premix
  • 0.25 kg (250g) Deracin 22% Granular Premix
  • 0.50 kg (500g) Chlor 50 Medicated Feed Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 5 days after the latest treatment with this drug when fed at the recommended level of 55 mg/kg (0.0055%) chlortetracycline hydrochloride in the complete feed.
  2. Do not administer to lactating dairy cattle.
  3. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  4. Keep out of reach of children. (Required on premix and supplement labels only)

Accepted Compatibilities

Nil

Calves (milk replacers)

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1
  1. Chlor 50 Medicated Feed Premix
Chlortetracycline (equivalent to chlortetracycline hydrochloride) at 110 g/kg
Claim 1
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Chlortetracycline hydrochloride at 220 g/kg
Claim 1
  1. Deracin 22% Granular Premix
Chlortetracycline calcium complex equivalent to chlortetracycline hydrochloride at 220 g/kg

Approved for use in milk replacers

Claim 1

As an aid in the prevention of bacterial diarrhea in calves.

Level of medicating ingredient in a complete feed

55 mg/kg (0.0055%) of chlortetracycline hydrochloride in milk replacer powder.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed continuously during periods of early growth.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 55 mg/kg (0.0055%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of milk replacer powder:

  • 0.25 kg (250g) Aureomycin 220 G Granular Medicated Premix
  • 0.25 kg (250g) Chlor 100 Granular Medicated Premix
  • 0.25 kg (250g) Deracin 22% Granular Premix
  • 0.50 kg (500g) Chlor 50 Medicated Feed Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 5 days after the latest treatment with this drug when fed at the recommended level of 55 mg/kg (0.0055%) chlortetracycline hydrochloride in the complete feed.
  2. Do not administer to lactating dairy cattle.
  3. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  4. Keep out of reach of children. (Required on premix and supplement labels only)

Accepted Compatibilities

Nil

Lambs

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1
  1. Aureomycin 220 G Granular Medicated Premix
  2. Chlor 100 Granular Medicated Premix
Chlortetracycline hydrochloride at 220 g/kg

Claim 1

As an aid in reduction of losses due to Enterotoxemia in feedlot lambs.

Level of medicating ingredient in a complete feed

22 mg/kg (0.0022%) of chlortetracycline hydrochloride in the complete feed.

Directions for use in a complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed this medicated feed as the sole ration while lambs are in the feedlot.

Additional information (not to appear on feed labels)

For feed manufacturers
Add and mix thoroughly into the ration at the following rate to provide 22 mg/kg (0.0022%) chlortetracycline hydrochloride per metric tonne (1,000 kg) of finished (complete) feed:

  • 0.10 kg (100g) Aureomycin 220 G Granular Medicated Premix
  • 0.10 kg (100g) Chlor 100 Granular Medicated Premix

Warning

  1. Treated animals must not be slaughtered for use in food for at least 4 days after the latest treatment with this drug when fed at the recommended level of 22 mg/kg (0.0022%) chlortetracycline hydrochloride in the complete feed.
  2. When handling the product avoid inhalation, oral exposure, and direct contact with skin or eyes. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Accepted Compatibilities

Nil

Date modified: